An Investigation of the Impact of Common Experimental Parameters on Signal Intensity in SFC ESI MS
نویسندگان
چکیده
In the past decade, supercritical fluid chromatography (SFC) has experienced a steady growth in acceptance, particularly in pharmaceutical and chemical laboratories. In SFC, a “supercritical” fluid, most commonly CO2, in combination with one or more polar organic solvents, such as alcohols, is used as mobile phase. Compared to HPLC, SFC offers better selectivity and shorter analysis time due to the low viscosity and high diffusivity inherent to supercritical fluids [1]. The ongoing acetonitrile (ACN) shortage has also stimulated an elevated interest in employing SFC as a possible alternative to the industry-dominating, ACN-reliant reversed phase LC (RPLC).
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